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Downs, of Menomonee Falls, researches the process of normalk egg maturationin mammals, specifically the metabolidc pathways that help regulate development of oocytes unfertilized egg cells. Understanding how these metabolic pathways regulate normal maturation is important because abnormalities in the processw can lead to abnormal developmentof eggs, manifestec in chromosomal irregularities such as Down While Downs said he focuses mainly on the most scientific level of understandinhg egg maturation, he is inspiredf by the applications of his research.
In addition to betterf understanding causes of Down his research applications include optimizing fertility treatments and diabetees treatmentand prevention. His research also has been appliedc to maximizing fertility efficiency in domestic livestock by perfectinh invitro procedures. “There’s nothingf like coming into the lab and finding out that thedata you’ved collected matches what you hypothesized would he said in a statement. “It’s that excitement of discover that keeps me coming backfor more.” Most Downs’ work has focused on the effectw of a stress-response protein on regulatint oocyte maturation in mice.
Results of these studies coulr show a connectionbetween physical, chemical and metabolic stress and abnormalitiexs in development. Downs was selected for the awardby Marquette’e Committee on Research and received $5,000.
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